UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

B9EKR1
Entry Name

PTPRZ_MOUSE
Protein Name

Receptor-type tyrosine-protein phosphatase zeta
Primary Gene Name

Ptprz1
Organism

Mus musculus (Mouse)
Molecular Function

Hydrolase
Protein phosphatase
Membrane Location

Secreted
Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Receptor-type tyrosine-protein phosphatase Z (Ptprz)
Cell Type
Substrate Description protein tyrosine phosphatase (PTP) family. negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes.
Substrate Function Category enzyme
Substrate Function Subtype
Sheddase ADAM17
Shedding-related Disease receptor-type PTPases
Short Summary of Papers Ptprz sequentially undergoes ectodomain shedding and RIP(regulated intramembrane proteolysis) by the γ-secretase suggest a novel signaling mechanism of Ptprz by the regulated proteolytic processing in the central nervous system.
Cleavage Information ZNo-Human:
PMID 18713734



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		25 1637
Transmembrane
 		1638 1658



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER LESE*KKAV 1631 ADAM17 synthetic peptide 18713734   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
PAPER neuron 22728825