UniProt Summary Literature Review Cleavage Sites Topological Domains Proteolytic Cleavage Secretome Detection
UniProt Summary
UniProt ID

A2A863
Entry Name

ITB4_MOUSE
Protein Name

Integrin beta-4
Primary Gene Name

Itgb4
Organism

Mus musculus (Mouse)
Molecular Function

Receptor
Integrin
Membrane Location

Cell membrane
Membrane



Biological Literature Report of Shedding
Substrate Name Integrin beta-4
Cell Type
Substrate Description integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome
Substrate Function Category disease
Substrate Function Subtype
Sheddase MMP9
Shedding-related Disease epithelial erosion
Short Summary of Papers cleavage of the β4 integrin ectodomain by MMP9 lead to recurrent epithelial erosions during erosion formation
Cleavage Information NONE
PMID 21750188



Cleavage Site Diagram



Topological Domains
Topological Domains
 		Start End
Extracellular
 		29 712
Transmembrane
 		713 733



Proteolytic Cleavage
Database CutSeq Mapped Position Protease Type Evidence PMID
PAPER No_information MMP9 NONE 21750188   



Secretome Detection
Secretome Database Cell Type or Body Fluid PubMed Reference
SPD 22728825